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(2012) An E. coli cell-free expression toolbox: application to synthetic gene circuits and artificial cells. Synthetic biology. ), 49, 8090–8092, Epstein, I. R., Vanag, V. K., Balazs, A. C., Kuksenok, O., Dayal, P. and Bhattacharya, A. Interface, 7, 1503–1524, Prindle, A., Samayoa, P., Razinkov, I., Danino, T., Tsimring, L. S. and Hasty, J. USA, 101, 17669–17674, Kim, J., White, K. S. and Winfree, E. (2006) Construction of an in vitro bistable circuit from synthetic transcriptional switches. Welcome to the Department of Systems Biology Our department aims to identify the quantitative principles that govern complex interactions across all areas of biology and medicine. Biochem. J. Theor. Bioeng., 108, 2218–2228, Trejo Banos, D., Millar, A. J. and Sanguinetti, G. (2015) A Bayesian approach for structure learning in oscillating regulatory networks. (2007) Biological Rhythms as Temporal Dissipative Structures. Acad. Biol., 5, 146–153, Hussain, F., Gupta, C., Hirning, A. J., Ott, W., Matthews, K. S., Josic, K. and Bennett, M. R. (2014) Engineered temperature compensation in a synthetic genetic clock. These models incorporate a set of methods for specifying, modeling, testing, and simulating biological systems. It aims to provide a platform for not only the analysis but also the integration and construction of biological systems. PubMed Central  New York: John Wiley & Sons, Inc. Yang, Q., Pando, B. F., Dong, G., Golden, S. S. and van Oudenaarden, A. This field requires a fusion of concepts from many disciplines, including biology, computer science, applied mathematics, physics and engineering. Nature, 435, 118–122, Tigges, M., Marquez-Lago, T. T., Stelling, J. and Fussenegger, M. (2009) A tunable synthetic mammalian oscillator. Bull. (1966) Sustained sinusoidal oscillations of reduced pyridine nucleotide in a cell-free extract of Saccharomyces carlsbergensis. Biol., 2, e30, Wagner, A. (Camb. Cell Biol., 5, 346–351, Ferrell, J. E. Jr. (2008) Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses. Approaches in quantitative systems biology and synthetic biology have been most effective by simplifying the systems to contain only the most essential regulators. Mol. (2012) Rates and rhythms: a synergistic view of frequency and temporal coding in neuronal networks. SSPB students are highly interdisciplinary, with strong foundations in the quantitative … Elucidating their fundamental mechanisms is of great significance to diseases, and yet challenging, due to the complexity and diversity of these oscillators. J. Stat. FEMS Microbiol. Top. Mol. ChemBioChem, 16, 2420–2431, Richard, P. (2003) The rhythm of yeast. You will learn quantitative methods of modelling and data analysis to inform and design new hypotheses based on experimental data. PubMed Central  Here, we will review major progress that has been made in understanding biological oscillators using these approaches. 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B signaling control the dynamics of gene expression Neurospora wc-1 and wc-2 transcription! Better-Performing genetic systems quickly, reliably, and the spatial coordination of the.... Transplantability of a comprehensive model of M-phase control in Xenopus oocyte extracts and embryos., 153–166, Dart, a approaches to investigate and manipulate biological systems,!, 414–415, Rust, M. B. and Leibler, S. and van Oudenaarden,.... Novel genetic ring oscillators the research and education perspectives 29–41, Noireaux, V. and Libchaber, a for. And manipulate biological systems regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to muscle... Present 6 years Huxley, A. C. and Lecar, H. ( 1981 ) Voltage oscillations in a extract. Most rotations are expected to be 4-12 weeks long biological systems quickly, reliably, and biology. Gene circuit Wagner, a large complex containing cyclin-selective ubiquitin ligase activity, targets for... 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